Tuberculin skin test reactivity is dependent on host genetic background in Colombian tuberculosis household contacts.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 22291100.
- Also identified by DOI 10.1093/cid/cir972 and PMC identifier 3297651.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The tuberculin skin test (TST) measures the intensity of antimycobacterial acquired immunity and is used to diagnose latent infection with Mycobacterium tuberculosis. We report evidence for a codominant gene explaining ∼65% of the TST variability. Disregarding the host genetic background may lead to misclassifications of TST-based diagnosis of latent M. tuberculosis infection.
Medical subject headings
- Genetic Variation
- Latent Tuberculosis
- Mycobacterium tuberculosis
- Tuberculin Test