Computational and statistical analysis of protein mass spectrometry data.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 22291580.
- Also identified by DOI 10.1371/journal.pcbi.1002296 and PMC identifier 3266873.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
High-throughput proteomics experiments involving tandem mass spectrometry produce large volumes of complex data that require sophisticated computational analyses. As such, the field offers many challenges for computational biologists. In this article, we briefly introduce some of the core computational and statistical problems in the field and then describe a variety of outstanding problems that readers of PLoS Computational Biology might be able to help solve.
Medical subject headings
- Computational Biology
- Mass Spectrometry
- Proteins