The long and short of microRNAs in the kidney.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22302196.
- Also identified by DOI 10.1681/ASN.2011080797 and PMC identifier 3294314.
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Abstract
MicroRNAs (miRNAs) are a group of small, noncoding RNAs that act as novel regulators of gene expression through the post-transcriptional repression of their target mRNAs. miRNAs have been implicated in diverse biologic processes, and it is estimated that up to half of all transcripts are regulated by miRNAs. Recent studies also demonstrate a critical role for miRNAs in renal development, physiology, and pathophysiology. Understanding the function of miRNAs in the kidney may lead to innovative approaches to renal disease.
Medical subject headings
- Gene Expression Regulation
- Kidney
- MicroRNAs