Phospho-specific flow: fixating on the target.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22302900.
- Also identified by DOI 10.1158/1078-0432.CCR-11-3266 and PMC identifier 3306466.
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Abstract
Targeted therapies are all the rage in oncology research these days. The problem remains as to how to confirm that the target is actually being hit in vivo. This report describes the application of phospho-specific flow cytometry to establish in vivo target inhibition in real time.
Medical subject headings
- Antineoplastic Combined Chemotherapy Protocols
- Leukemia, Myeloid, Acute
- Ribosomal Protein S6
- Sirolimus
- TOR Serine-Threonine Kinases