Finding a target for resveratrol.
basic_science · Level V
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- Record sourced from PubMed, PMID 22304906.
- Also identified by DOI 10.1016/j.cell.2012.01.032.
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Abstract
Despite resveratrol's well-documented health benefits, its mechanism of action remains controversial. In particular, the direct molecular target of resveratrol has been elusive. Park et al. now show that resveratrol directly inhibits cAMP-dependent phosphodiesterases, triggering a cascade of events that converge on the important energy-sensing metabolic regulators AMPK, SIRT1, and PGC-1α.