Immune cells exploit a neural circuit to enter the CNS.
basic_science · Level V
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- Record sourced from PubMed, PMID 22304908.
- Also identified by DOI 10.1016/j.cell.2012.01.025 and PMC identifier 4544704.
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Abstract
Multiple sclerosis (MS) is associated with the appearance of autoreactive T cells in the central nervous system. Using a mouse model of MS, Arima et al. now show that this attack begins at a specific spinal cord location. T cell entry into the CNS is regulated by a reflex neural circuit originating from leg muscle contractions.