A new histone at the centromere?
basic_science · Level V
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- Record sourced from PubMed, PMID 22304909.
- Also identified by DOI 10.1016/j.cell.2012.01.023 and PMC identifier 3404608.
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Abstract
The centromere is a classic system to study epigenetic specification, and most research has focused on a specialized histone variant, CENP-A, that is required for kinetochore assembly. Now Nishino et al. reveal a new level of complexity for centromeric chromatin, by showing that the kinetochore complex CENP-T-W-S-X shares structural and functional properties with canonical histones.