Hypoxia-inducible factors in physiology and medicine.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 22304911.
- Also identified by DOI 10.1016/j.cell.2012.01.021 and PMC identifier 3437543.
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Abstract
Oxygen homeostasis represents an organizing principle for understanding metazoan evolution, development, physiology, and pathobiology. The hypoxia-inducible factors (HIFs) are transcriptional activators that function as master regulators of oxygen homeostasis in all metazoan species. Rapid progress is being made in elucidating homeostatic roles of HIFs in many physiological systems, determining pathological consequences of HIF dysregulation in chronic diseases, and investigating potential targeting of HIFs for therapeutic purposes.
Medical subject headings
- Basic Helix-Loop-Helix Proteins
- Biological Evolution
- Oxygen