Stem-cell-like qualities of immune memory; CD4+ T cells join the party.
review · Level V
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- Record sourced from PubMed, PMID 22305557.
- Also identified by DOI 10.1016/j.stem.2012.01.011 and PMC identifier 3277283.
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Abstract
Similar to hematopoietic stem cells, memory lymphocytes self-renew, while their clonally expanded effector progeny differentiate to fight infection and tumors. Recently, Muranski et al. (2011) report in Immunity that a subset of Th17 effector cells function as memory cells and retain stem cell properties.