Periostin: a bridge between cancer stem cells and their metastatic niche.
review · Level V
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- Record sourced from PubMed, PMID 22305559.
- Also identified by DOI 10.1016/j.stem.2012.01.002.
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Abstract
Only a minority of cancer cells have the potential to initiate metastatic growth, but the factors that limit metastatic colonization remain mostly unknown. Malanchi et al. (2012) recently demonstrated that stromal periostin is crucial for metastatic colonization by regulating the interactions between breast cancer stem cells and their metastatic niche.