Ironing out tau's role in parkinsonism.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 22310680.
- Also identified by DOI 10.1038/nm.2668 and PMC identifier 4455923.
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Abstract
Parkinson's disease affects more than five million people worldwide, yet no therapeutic has been identified that can slow or halt the progression of this debilitating disease. A new study in tau knockout mice suggests that tau deficiency causes impaired ferroportin-coupled iron export, by retention of the amyloid precursor protein, a neuronal ferroxidase partner, in the endoplasmic reticulum. This leads to parkinsonism through intracellular iron accumulation and degeneration of dopamine neurons (pages X-Y).
Medical subject headings
- Amyloid beta-Protein Precursor
- Dementia
- Iron
- Parkinsonian Disorders
- tau Proteins