Imaging tumor sensitivity to a bioreductive prodrug: two for the price of one!
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22317761.
- Also identified by DOI 10.1158/1078-0432.CCR-11-3267.
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Abstract
Hypoxia is an important characteristic of many solid tumors and has a major negative effect on treatment response. A way to combat this effect is with drugs called "bioreductive prodrugs" or "hypoxic cytotoxins," which are metabolized under hypoxia to toxic species. However, the patients with hypoxic tumors need to be identified.
Medical subject headings
- Calcium-Binding Proteins
- Cell Cycle Proteins
- Etanidazole
- Hydrocarbons, Fluorinated