Density gradient multilayer polymerization for creating complex tissue.

Karpiak, Jerome V; Ner, Yogesh; Almutairi, Adah · Adv Mater · 2012

basic_science · Level V

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Abstract

An adaptable density gradient multilayer polymerization (DGMP) method facilitates simple fabrication of complex multicompartment scaffolds with structurally continuous interfaces. Solvent density liquid-liquid phase segregation compartmentalizes varied mechanical and chemical cues independently. Bulk photopolymerization produces stratified three-dimensional and two-dimensional matrices. Cells attach to patterned adhesion peptides on biomimetic 2D substrates.

Medical subject headings