Mesoporous silica-coated gold nanorods as a light-mediated multifunctional theranostic platform for cancer treatment.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22318874.
- Also identified by DOI 10.1002/adma.201104714.
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Abstract
Mesoporous silica-coated gold nanorods (Au@SiO(2)) are developed as a promising and versatile theranostic platform for cancer treatment. Intracellular localization of Au@SiO(2) is visualized through two-photon imaging. With doxorubicin hydrochloride loaded, Au@SiO(2)-DOX show two light-mediated therapeutic modes: low power density laser-triggered drug release for chemotherapy, and high power density laser-induced hyperthermia, which suggest the potential for in-vivo applications.
Medical subject headings
- Gold
- Light
- Metal Nanoparticles
- Neoplasms
- Photosensitizing Agents
- Silicon Dioxide