Neuron transplantation partially reverses an obesity disorder in mice.
basic_science · Level V
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- Record sourced from PubMed, PMID 22326215.
- Also identified by DOI 10.1016/j.cmet.2012.01.011.
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Abstract
Mice lacking leptin receptors are grossly obese and diabetic, in part due to dysfunction in brain circuits important for energy homeostasis. Transplantation of leptin receptor-expressing hypothalamic progenitor neurons into the brains of leptin receptor deficient mice led to integration into neural circuits, reduced obesity, and normalized circulating glucose levels.