Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies.
basic_science · Level V
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- Record sourced from PubMed, PMID 22327622.
- Also identified by DOI 10.1038/nm.2673 and PMC identifier 3916180.
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Abstract
Applying a next-generation sequencing assay targeting 145 cancer-relevant genes in 40 colorectal cancer and 24 non-small cell lung cancer formalin-fixed paraffin-embedded tissue specimens identified at least one clinically relevant genomic alteration in 59% of the samples and revealed two gene fusions, C2orf44-ALK in a colorectal cancer sample and KIF5B-RET in a lung adenocarcinoma. Further screening of 561 lung adenocarcinomas identified 11 additional tumors with KIF5B-RET gene fusions (2.0%; 95% CI 0.8-3.1%). Cells expressing oncogenic KIF5B-RET are sensitive to multi-kinase inhibitors that inhibit RET.
Medical subject headings
- Carcinoma, Non-Small-Cell Lung
- Colorectal Neoplasms
- Kinesins
- Lung Neoplasms
- Oncogene Proteins, Fusion
- Proto-Oncogene Proteins c-ret
- Receptor Protein-Tyrosine Kinases