Requirement for hsp70 in the mitochondrial matrix for translocation and folding of precursor proteins.
basic_science · Level V
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Abstract
By analysis of a temperature-sensitive yeast mutant, a heat-shock protein in the matrix of mitochondria, mitochondrial hsp70 (Ssc1p), is found to be involved both in translocation of nuclear-encoded precursor proteins across the mitochondrial membranes and in (re)folding of imported proteins in the matrix.