CoSMoS unravels mysteries of transcription initiation.
basic_science · Level V
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- Record sourced from PubMed, PMID 22341438.
- Also identified by DOI 10.1016/j.cell.2012.01.042 and PMC identifier 3681408.
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Abstract
Using a fluorescence method called colocalization single-molecule spectroscopy (CoSMoS), Friedman and Gelles dissect the kinetics of transcription initiation at a bacterial promoter. Ultimately, CoSMoS could greatly aid the study of the effects of DNA sequence and transcription factors on both prokaryotic and eukaryotic promoters.