Transmitter time: synaptic plasticity and metabolic memory in the hypothalamus.
basic_science · Level V
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- Record sourced from PubMed, PMID 22342702.
- Also identified by DOI 10.1016/j.cmet.2012.01.014.
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Abstract
Hunger elicits feeding behavior by activating Agouti-related peptide (AgRP) neurons. Two recent studies show how fasting, or the hunger hormone ghrelin, promote excitatory glutamate release onto AgRP neurons (Yang et al., 2011) and increase postsynaptic glutamate receptor-mediated drive (Liu et al., 2012).