Blockade of PDGFR-β activation eliminates morphine analgesic tolerance.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22344297.
- Also identified by DOI 10.1038/nm.2633 and PMC identifier 3296828.
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Abstract
For centuries, opioid drugs have been the mainstay of chronic pain treatment. However, over time analgesic tolerance develops, leaving few treatment options. Here we show that platelet-derived growth factor receptor-β (PDGFR-β)-mediated signaling plays a key role in morphine tolerance. PDGFR-β inhibition selectively eliminates morphine tolerance in rats. PDGFR-β inhibitors are widely used and well tolerated, suggesting that clinical translation of our findings could reduce the suffering endured by individuals with intractable pain.
Medical subject headings
- Chronic Pain
- Drug Tolerance
- Morphine
- Receptor, Platelet-Derived Growth Factor beta
- Receptors, Opioid, mu
- Transcriptional Activation