Osteocyte RANKL: new insights into the control of bone remodeling.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 22354849.
- Also identified by DOI 10.1002/jbmr.1547 and PMC identifier 3449092.
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Abstract
The idea that osteoblasts, or their progenitors, support osteoclast formation by expressing the cytokine receptor activator of NFkB ligand (RANKL) is a widely held tenet of skeletal biology. Two recent studies provide evidence that osteocytes, and not osteoblasts or their progenitors, are the major source of RANKL driving osteoclast formation in cancellous bone. The goal of this review is to highlight the results of these new studies and discuss their implications for our understanding of bone remodeling.
Medical subject headings
- Bone Remodeling
- Osteocytes
- RANK Ligand