Generalized multiple-layer appearance of the cerebral cortex with 3D FLAIR 7.0-T MR imaging.

Abstract

To examine the multiple-layer appearance of the cerebral cortex with fluid-attenuated inversion recovery (FLAIR) magnetic resonance (MR) imaging at 7.0 T, whole-brain volumetric three-dimensional (3D) magnetization prepared FLAIR images were acquired in 12 volunteers (0.8 3 0.8 3 0.8-mm spatial resolution). Signal intensity profiles were evaluated for the anterior frontal (Brodmann area [BA] 10), posterior frontal (BA 6), parietal (BA 7), precentral (BA 4), postcentral (BA 3), occipital (BA 18), and calcarine (BA 17) regions. Variance of the normalized profile was used as the metric for the multiple-layer appearance. Wilcoxon signed-rank tests were performed to compare variances of the profiles between all areas. All cortical areas showed multiple-layered appearances, with a prominent hyperintense band at the external surface of the cortex, a hypointense band deeper in the cortex, and a hyperintense third band. The ranking from least- to most-pronounced layer appearance was as follows: postcentral (variance, 0.04), posterior frontal (variance, 0.05), calcarine (variance, 0.05), precentral (variance, 0.06), parietal (variance, 0.08), anterior frontal (variance, 0.10), and occipital (variance, 0.11). Each region was significantly different from at least one other region. In conclusion, a multiple-layer appearance of the cerebral cortex was found for all cortical regions with high-spatial-resolution 3D FLAIR MR imaging at 7.0 T.