Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3.
basic_science · Level V
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- Record sourced from PubMed, PMID 22371083.
- Also identified by DOI 10.1038/nbt.2141 and PMC identifier 4617627.
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Abstract
Insulin-expressing cells that have been differentiated from human pluripotent stem cells in vitro lack the glucose responsiveness characteristic of mature beta cells. Beta-cell maturation in mice was studied to find genetic markers that enable screens for factors that induce bona fide beta cells in vitro. We find that functional beta-cell maturation is marked by an increase in the glucose threshold for insulin secretion and by expression of the gene urocortin 3.
Medical subject headings
- Glucose
- Insulin-Secreting Cells
- Urocortins