Chinese herbs nephropathy and Balkan endemic nephropathy: toward a single entity, aristolochic acid nephropathy.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 22373701.
- Also identified by DOI 10.1038/ki.2011.428.
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Abstract
Chinese herbs nephropathy (CHN) and Balkan endemic nephropathy (BEN) are chronic tubulointerstitial renal diseases associated with urothelial carcinoma. The clinical expression and pathological lesions observed at different stages of CHN and BEN are strikingly similar. Both have been linked to exposure to aristolochic acid (AA), a powerful nephrotoxin and human carcinogen. Jelaković et al. present molecular epidemiological evidence relating urothelial carcinoma in patients with BEN to dietary exposure to AA. It is time to abandon the terms 'CHN' and 'BEN' and introduce 'aristolochic acid nephropathy' to cover both clinical conditions.
Medical subject headings
- Aristolochic Acids
- Balkan Nephropathy
- Carcinogens, Environmental
- Carcinoma
- DNA Adducts
- Environmental Exposure
- Kidney Cortex
- Urologic Neoplasms