The efficiency of the human CD8+ T cell response: how should we quantify it, what determines it, and does it matter?
expert_opinion · Level V
Where this comes from
- Record sourced from PubMed, PMID 22383867.
- Also identified by DOI 10.1371/journal.pcbi.1002381 and PMC identifier 3285570.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Multidisciplinary techniques, in particular the combination of theoretical and experimental immunology, can address questions about human immunity that cannot be answered by other means. From the turnover of virus-infected cells in vivo, to rates of thymic production and HLA class I epitope prediction, theoretical techniques provide a unique insight to supplement experimental approaches. Here we present our opinion, with examples, of some of the ways in which mathematics has contributed in our field of interest: the efficiency of the human CD8+ T cell response to persistent viruses.
Medical subject headings
- CD8-Positive T-Lymphocytes