Nanoscale E-cadherin ligand patterns show threshold size for cellular adhesion and adherence junction formation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22385254.
- Also identified by DOI 10.1021/nl300514v.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The role of ligand spatial distribution on the formation of cadherin mediated cell-cell contacts is studied utilizing nanopatterns of E-cadherin ligands. Protein patches ranging in size from 100 to 800 nm prepared by colloidal lithography critically influence adhesion, spreading, and formation of adherence junctions in epithelial cells. Cells at 100 nm patterns show poor adhesion, while larger pattern sizes show good adhesion, significant spreading, and defined cortical actin. We estimate a threshold of 0.03 μm(2) for epithelial cellular attachment via E-Cadherin.
Medical subject headings
- Cadherins
- Epithelial Cells
- Gold
- Metal Nanoparticles