Where PI3K/Akt meets Smads: the crosstalk determines human embryonic stem cell fate.
basic_science · Level V
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- Record sourced from PubMed, PMID 22385648.
- Also identified by DOI 10.1016/j.stem.2012.02.008 and PMC identifier 3586792.
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Abstract
Coordinated interactions between signaling networks govern the balance of cell fate decisions in human embryonic stem cells. In this issue, Singh et al. (2012) report that PI3K/Akt signaling switches Activin/Smad activity between pro-self-renewal and prodifferentiation by regulating ERK and GSK3β/β-catenin signaling.