iPSCs to the rescue in Alzheimer's research.
basic_science · Level V
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- Record sourced from PubMed, PMID 22385650.
- Also identified by DOI 10.1016/j.stem.2012.02.011.
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Abstract
A crucial limitation to our understanding of Alzheimer's disease has been the inability to test hypotheses on live, patient-specific neurons. A recent study in Nature by Israel et al. (2012) reports that iPSC-derived neurons from AD patients recapitulate multiple aspects of disease pathology.