Greasing the path to BAX/BAK activation.
basic_science · Level V
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- Record sourced from PubMed, PMID 22385953.
- Also identified by DOI 10.1016/j.cell.2012.02.006.
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Abstract
BAX/BAK activation leading to mitochondrial outer-membrane permeabilization is a key commitment point in apoptosis. Chipuk et al. now identify two sphingolipids as specific cofactors for BAX/BAK activation that lower the threshold for apoptosis-associated cytochrome c release. Association of mitochondria with other cellular membrane compartments is required for BAK/BAX exposure to these sphingolipids.