DNA-damage-induced differentiation in hematopoietic stem cells.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22385954.
- Also identified by DOI 10.1016/j.cell.2012.02.011.
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Abstract
Aging of hematopoietic stem cells (HSCs) is accompanied by diminished functional potential. Wang et al. now provide evidence for an HSC-specific differentiation checkpoint mediated by the transcription factor BATF, which limits self-renewal of HSCs in response to the accumulation of DNA damage.
Medical subject headings
- Cell Cycle Checkpoints
- Cell Differentiation
- Cellular Senescence
- DNA Damage
- Hematopoietic Stem Cells