Fast gapped-read alignment with Bowtie 2.
Where this comes from
- Record sourced from PubMed, PMID 22388286.
- Also identified by DOI 10.1038/nmeth.1923 and PMC identifier 3322381.
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Abstract
As the rate of sequencing increases, greater throughput is demanded from read aligners. The full-text minute index is often used to make alignment very fast and memory-efficient, but the approach is ill-suited to finding longer, gapped alignments. Bowtie 2 combines the strengths of the full-text minute index with the flexibility and speed of hardware-accelerated dynamic programming algorithms to achieve a combination of high speed, sensitivity and accuracy.
Medical subject headings
- Algorithms
- Computational Biology
- Sequence Alignment