Statins personalized.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 22391257.
- Also identified by DOI 10.1016/j.mcna.2011.11.004.
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Abstract
3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor medications, commonly referred to as statins, are among the most widely prescribed medications. Variation in individual response to statins concerning low-density lipoprotein cholesterol reduction, clinical event benefit, and side effects has been observed. Some of this variability is attributed to demographic and environmental issues, chief of which is compliance. A large portion of the individual response to statin therapy is attributed to single nucleotide polymorphisms that have recently been elucidated, several of which seem to have clinical utility.
Medical subject headings
- Drug Resistance
- Dyslipidemias
- Hydroxymethylglutaryl CoA Reductases
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
- Lipid Metabolism
- Precision Medicine