Effect of preoperative rescue concomitant FUN/XUN-based chemo-radiotherapy for neoadjuvant chemotherapy-refractory breast cancer.

Bourgier, Céline; Ghorbel, Ismael; Heymann, Steve; Barhi, Manel; Mazouni, Chafika; Al Ghuzlan, Abir Al; Balleyguier, Corinne; Marsiglia, Hugo et al. · Radiother Oncol · 2012

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Abstract

Even though tumor progression under neoadjuvant chemotherapy is uncommon, its locoregional management remains absolutely unclear. What is the best time for radical surgery or radiotherapy? "Rescue" chemo-radiotherapy could be a suitable radiosensitizing strategy to further reduce tumor progression and allow curative surgery while maintaining systemic therapy.

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