A patient with tyrosine kinase 2 deficiency without hyper-IgE syndrome.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 22402565.
- Also identified by DOI 10.1016/j.jpeds.2012.01.056 and PMC identifier 3360808.
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Abstract
We describe a Turkish patient with tyrosine kinase 2 deficiency who suffered from disseminated Bacille Calmette-Guerin infection, neurobrucellosis, and cutaneous herpes zoster infection. Tyrosine kinase 2 deficiency should be considered in patients susceptible to herpes viruses and intramacrophage pathogens even in the absence of atopy, high serum IgE, and staphylococcal disease.
Medical subject headings
- Immunologic Deficiency Syndromes
- TYK2 Kinase