Diffusion-weighted MR imaging in differentiation between osteoporotic and neoplastic vertebral fractures.
cross_sectional · Level IV
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- Record sourced from PubMed, PMID 22411038.
- Also identified by DOI 10.1007/s00586-012-2227-x and PMC identifier 3325396.
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Abstract
To assess the usefulness of magnetic resonance imaging (MRI) with spin-echo echo-planar diffusion-weighted imaging (SE-EPI-DWI) in differentiation between vertebral osteoporotic fractures and pathological neoplastic fractures. Thirty-three patients with both osteoporotic or neoplastic vertebral fractures diagnosed with X-ray or TC were studied with MRI exam, (1.5 T unit) with DWI sequences. DWI sequences were qualitatively analyzed. Apparent diffusion coefficient (ADC) values were also determined and compared to the definitive histologic diagnosis. DWI of neoplastic lesions showed hyperintensity signal in 22 out of 23 cases. Mean ADC value of neoplastic fractures was 1.241 ± 0.4 × 10(-3) mm(2)/s; mean ADC value of osteoporotic fractures was 0.646 ± 0.368 × 10(-3) mm(2)/s. Neoplastic fractures showed ADC values significantly higher than osteoporotic ones (p < 0.001). DWI imaging and histology showed a significant correlation. DWI provides reliable information to support MRI diagnosis of neoplastic versus osteoporotic fractures. ADC value appears as a useful adjunctive parameter.
Medical subject headings
- Diffusion Magnetic Resonance Imaging
- Osteoporotic Fractures
- Spinal Fractures
- Spinal Neoplasms
- Thoracic Vertebrae
Anatomy
- thoracic spine