Triple stimulus-responsive polypeptide nanoparticles that enhance intratumoral spatial distribution.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22417133.
- Also identified by DOI 10.1021/nl300630c and PMC identifier 3474318.
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Abstract
To address the limited tumor penetration of nanoparticle drug delivery vehicles, we report the first pH-responsive polypeptide micelle that dissociates at the low extracellular pH of solid tumors. This histidine-rich elastin-like polypeptide block copolymer self-assembles at 37 °C into spherical micelles that are stabilized by Zn(2+) and are disrupted as the pH drops from 7.4 to 6.4. These pH-sensitive micelles demonstrate better in vivo penetration and distribution in tumors than a pH-insensitive control.
Medical subject headings
- Drug Carriers
- Micelles
- Nanoparticles
- Neoplasms
- Peptides