Increased risk of noninfluenza respiratory virus infections associated with receipt of inactivated influenza vaccine.

Cowling, Benjamin J; Fang, Vicky J; Nishiura, Hiroshi; Chan, Kwok-Hung; Ng, Sophia; Ip, Dennis K M; Chiu, Susan S; Leung, Gabriel M et al. · Clin Infect Dis · 2012

rct · Level II

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Abstract

We randomized 115 children to trivalent inactivated influenza vaccine (TIV) or placebo. Over the following 9 months, TIV recipients had an increased risk of virologically-confirmed non-influenza infections (relative risk: 4.40; 95% confidence interval: 1.31-14.8). Being protected against influenza, TIV recipients may lack temporary non-specific immunity that protected against other respiratory viruses.

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