Detecting overlapping protein complexes in protein-protein interaction networks.
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- Record sourced from PubMed, PMID 22426491.
- Also identified by DOI 10.1038/nmeth.1938 and PMC identifier 3543700.
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Abstract
We introduce clustering with overlapping neighborhood expansion (ClusterONE), a method for detecting potentially overlapping protein complexes from protein-protein interaction data. ClusterONE-derived complexes for several yeast data sets showed better correspondence with reference complexes in the Munich Information Center for Protein Sequence (MIPS) catalog and complexes derived from the Saccharomyces Genome Database (SGD) than the results of seven popular methods. The results also showed a high extent of functional homogeneity.
Medical subject headings
- Protein Interaction Mapping
- Protein Interaction Maps
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins