Preserved function of regulatory T cells in chronic HIV-1 infection despite decreased numbers in blood and tissue.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 22427677.
- Also identified by DOI 10.1093/infdis/jis236 and PMC identifier 3415814.
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Abstract
Regulatory T cells (Tregs) are potent immune modulators, but their role in human immunodeficiency virus type 1 (HIV-1) pathogenesis remains poorly understood. We performed a detailed analysis of the frequency and function of Tregs in a large cohort of HIV-1-infected individuals and HIV-1 negative controls. While HIV "elite controllers" and uninfected individuals had similar Treg numbers and frequencies, the absolute numbers of Tregs declined in blood and gut-associated lymphoid tissue in patients with chronic progressive HIV-1 infection. Despite quantitative changes in Tregs, HIV-1 infection was not associated with an impairment of ex vivo suppressive function of flow-sorted Tregs in both HIV controllers and untreated chronic progressors.
Medical subject headings
- HIV Infections
- HIV-1
- T-Lymphocytes, Regulatory