Walking nanothermometers: spatiotemporal temperature measurement of transported acidic organelles in single living cells.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22437040.
- Also identified by DOI 10.1039/c2lc00014h.
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Abstract
We fabricated fluorescent nanoparticles which monitor temperature changes without sensitivity to pH (4-10) and ionic strength (0-500 mM). The nanothermometers spontaneously enter living HeLa cells via endocytosis, enclosed in acidic organelles, i.e., endosome/lysosome, and then transported along microtubules in a temperature-dependent manner, working as "walking nanothermometers".
Medical subject headings
- Lysosomes
- Nanoparticles
- Nanotechnology
- Single-Cell Analysis
- Thermometers