Serum interleukin-16 levels in patients with nasal polyposis.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 22447494.
- Also identified by DOI 10.1002/lary.23238.
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Abstract
Several inflammatory and allergic disorders have been reported to correlate with interleukin-16 (IL-16). IL-16 is a highly potent chemotactic and chemoattractant molecule for eosinophils. Nasal polyposis (NP) has an inflammatory basis, and eosinophilia is a common finding in polyp tissue. In this study, we aimed to determine serum IL-16 levels in NP patients. Prospective controlled study in a tertiary academic hospital. Peripheral blood samples were obtained and used for serologic studies with enzyme-linked immunosorbent assay kits to determine IL-16 levels. The study and the control groups consisted of 17 and 10 patients, respectively. Mean serum IL-16 levels were significantly higher in the study group when compared to the control group (447.9 pg/mL vs. 260.2 pg/mL) (P < .001). Serum IL-16 levels are significantly elevated in NP patients. This finding may represent identification of a valuable serum biomarker and potential therapeutic target in NP patients.
Medical subject headings
- Interleukin-16
- Nasal Polyps