Effect of surface-functionalized nanoparticles on the elongation phase of beta-amyloid (1-40) fibrillogenesis.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22459190.
- Also identified by DOI 10.1016/j.biomaterials.2012.03.024.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The influence of nanoparticles of various sizes and surface functionalities on the self-assembling fibrillogenesis of beta-amyloid (1-40) peptide was investigated. Functionalized nanoparticles including quantum dots and gold nanoparticles were co-incubated with monomeric Aβ(1-40) peptides under seed-mediated growth method to study their influences on the elongation phase of the fibrillogenesis. It is observed that charge-to-surface area ratio of the nanoparticles and the functional moiety and electrostatic charges of the conjugated ligands on the particle surfaces took crucial regulatory role in the Aβ(1-40) fibrillogenesis.
Medical subject headings
- Amyloid beta-Peptides
- Metal Nanoparticles
- Peptide Fragments
- Quantum Dots