A possible mechanism of renal cell death after ischemia/reperfusion.
expert_opinion · Level V
Where this comes from
- Record sourced from PubMed, PMID 22460652.
- Also identified by DOI 10.1038/ki.2011.495 and PMC identifier 3324283.
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Abstract
Linkermann et al. provide the first evidence for a possible biochemical mechanism of necrotic kidney cell death associated with renal ischemia/reperfusion-induced acute kidney injury. The mechanisms of several pathways resulting in programmed necrosis were recently elucidated and rely on receptor-interacting protein kinases 1 and 3. Using an inhibitor of one of these kinases, Linkermann et al. were able to ameliorate functional and morphologic kidney damage after ischemia/reperfusion.
Medical subject headings
- Kidney
- Receptor-Interacting Protein Serine-Threonine Kinases
- Reperfusion Injury