The joy of six: how to control your crossovers.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22464316.
- Also identified by DOI 10.1016/j.cell.2012.03.011.
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Abstract
Meiotic cells tightly regulate the number and distribution of crossovers to promote accurate chromosome segregation. Yokoo and colleagues uncover a metazoan-specific, cyclin-like protein that is crucial for crossover formation. They utilize this protein's unique properties to explore a remarkable example of biological numerology, whereby nearly every meiotic cell in C. elegans makes precisely six crossovers, one for each of its six chromosome pairs.