Metformin and pancreatic cancer: a clue requiring investigation.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 22465829.
- Also identified by DOI 10.1158/1078-0432.CCR-12-0694.
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Abstract
Laboratory models show antineoplastic activity of metformin under certain conditions, and pharmacoepidemiologic studies have reported reduced cancer burden among diabetics taking metformin. Therefore, the hypothesis that metformin has antineoplastic activity is receiving increasing attention. However, gaps in knowledge must be addressed before metformin can be "repurposed" for oncologic indications.
Medical subject headings
- Antineoplastic Agents
- Diabetes Mellitus
- Metformin
- Pancreatic Neoplasms