Three-dimensional biomimetic patterning in hydrogels to guide cellular organization.
basic_science · Level V
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- Record sourced from PubMed, PMID 22467256.
- Also identified by DOI 10.1002/adma.201200395 and PMC identifier 3728891.
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Abstract
An image-guided micropatterning method is demonstrated for generating biomimetic hydrogel scaffolds with two-photon laser scanning photolithography. This process utilizes computational methods to directly translate three-dimensional cytoarchitectural features from labeled tissues into material structures. We use this method to pattern hydrogels that guide cellular organization by structurally and biochemically recapitulating complex vascular niche microenvironments with high pattern fidelity at the microscale.
Medical subject headings
- Biomimetic Materials
- Hydrogel, Polyethylene Glycol Dimethacrylate