Glucuronoxylomannan facilitates generation of chondrocytes from bone marrow-derived mononuclear cells.

Abstract

Chondrocyte generation is an important process in cartilage and bone repair. Factors facilitating the induction of chondrocyte need to be further investigated. The present study aims to investigate the role of glucuronoxylomannan (Gxm) in the generation of chondrocytes. Human bone marrow cells were prepared using to generate the chondrocytes in the presence of Gxm. The results showed that Gxm has the capacity to facilitate the generation of chondrocytes in which transforming growth factor (TGF)-β played a critical role. The Bmmc-derived CD14+ cells were the major source of TGF-β in the culture. The present study indicates that Gxm is a potential drug candidate to be used in the generation of chondrocyte.