Clinical and physical aspects of total body irradiation for bone marrow transplantation in Nijmegen.
case_series · Level IV
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- Record sourced from PubMed, PMID 2247634.
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Abstract
Eighty-nine patients were transplanted with allogeneic bone marrow after a standard conditioning regimen consisting of cyclophosphamide and fractionated total body irradiation (2 x 4.5 Gy) with average dose rates of 4.1 and 12.3 cGy/min, respectively. The average rectum and lung dose was 9.2 +/- 0.45 and 7.5 +/- 0.78 Gy. In vivo dosimetry was performed in 71 patients irradiated with 18 MV X-rays from left and right lateral. Forty-three patients (48%) died. After increasing the dose rate the incidence of interstitial pneumonitis increased, but the number of relapses decreased.
Medical subject headings
- Anemia
- Bone Marrow Transplantation
- Leukemia
- Myelodysplastic Syndromes
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
- Whole-Body Irradiation