Generation of transplantable striatal projection neurons from human ESCs.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22482498.
- Also identified by DOI 10.1016/j.stem.2012.03.004.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
In this issue of Cell Stem Cell, Ma et al. (2012) report a differentiation protocol for generating striatal projection neurons from human embryonic stem cells with high efficiency. The cells survive transplantation, reconnect striatal circuitry, and restore motor function in a mouse model of striatal neurodegeneration that mimics the central pathohology of Huntington's disease.