Targeting β-catenin in CML: leukemia stem cells beware!
basic_science · Level V
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- Record sourced from PubMed, PMID 22482499.
- Also identified by DOI 10.1016/j.stem.2012.03.006.
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Abstract
In this issue of Cell Stem Cell, Heidel et al. (2012) use genetic and pharmacological approaches to reveal that Wnt/β-catenin signaling is required for leukemic stem cell (LSC) maintenance in chronic myeloid leukemia. They demonstrate that β-catenin inactivation targets imanitib-resistant LSCs in vivo.